Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres

doi:10.3748/wjg.v25.i39.5991

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Oct 21, 2019 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Oct 21, 2019; 25(39): 5991-6005
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5991

Table 1 Demographic and clinical-pathological characteristics in patients with a diagnosis of mixed neuroendocrine non-neuroendocrine neoplasm

Variable	Category	n (%)	Variable	Category	n (%)
Gender			Predominant component
	Female	25 (36.2)		NE	27 (39.1)
	Male	44 (63.8)		Non-NE	12 (17.4)
				Equal proportion	7 (10.1)
				NA	23 (33.3)
Disease stage			Morphology of NE component
	Localised	37 (53.6)		Large cell	13 (18.8)
	Advanced	30 (43.5)		Small cell	5 (7.2)
	NA	2 (2.9)		Others	1 (1.4)
				NA	50 (72.4)
Primary tumour site			Grading of NE component
	Colon	22 (31.9)		Grade 1	3 (4.3)
	Oesophagus/OGJ	11 (15.9)		Grade 2	14 (20.3)
	Rectum	8 (11.6)		Grade 3	57 (82.6)
	Small bowel/ICJ	8 (11.6)		NA	3 (4.3)
	Pancreas	6 (8.7)
	Stomach	4 (5.8)	Ki-67 of NE component
	Anus	4 (5.8)		Median	70% (55-68)
	Biliary tract	3 (4.3%)		< 55%	19 (27.5)
	Appendix	2 (1.9)		≥ 55%	37 (53.6)
	Unknown	1 (1.5)		NA	13 (18.8)
			Histology of non-NE component
	Lower GI	44 (63.8)		ADC	51 (39.1)
	Upper GI	15 (21.7)		Adenoma	2 (17.4)
	PB	9 (13)		Carcinoma/SCC	1 (10.1)
	Unknown	1 (1.5)		NA	15 (33.3)
			Grading of non- NE component
				Grade 1	10 (14.5)
				Grade 2	14 (20.3)
				Grade 3	20 (29.0)
				Adenoma	2 (17.4)
				NA	23 (33.3)

Note: the sum of the percentages might not reach 100% due to rounding. ECOG: Eastern Cooperative Oncology Group; PS: Performance status; Loc: Localised stage; Adv: Advanced stage; NE: Neuroendocrine; ADC: Adenocarcinoma; SCC: Squamous cell carcinoma; OE: Oesophageal; OGJ: Oesophago-gastric junction; ICJ: Ileo-caecal junction; Lower GI: Lower gastrointestinal tract; Upper GI: Upper gastrointestinal tract; PB: Pancreatico-biliary tract; NA: Not available.

Citation: Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG. Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres. World J Gastroenterol 2019; 25(39): 5991-6005
URL: https://www.wjgnet.com/1007-9327/full/v25/i39/5991.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i39.5991