Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis

Figure 8 Sirtuin 1 activation suppresses endoplasmic reticulum stress-mediated apoptotic pathways during dextran sodium sulfate-induced colitis. The protein levels of SIRT1, GRP78, CHOP, cleaved caspase-12, cleaved caspase-9, and cleaved caspase-3 in colon tissues were detected by Western blot. UC: Ulcerative colitis; NAM: Nicotinamide; GRP78: Glucose-regulated protein 78; CHOP: CCAAT/enhancer-binding protein homologous protein; SIRT1: Sirtuin 1.