Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele

Table 3 Effect of APOE alleles on lipid profile and lipid abnormalities of hepatitis C virus patients

	Chronic			Clearance
	E2 (n = 19)	E3 (n = 160)	E4 (n = 27)	E2 (n = 8)	E3 (n = 64)	E4 (n = 21)
Lipid profile
TC, mg/dL	140.6 ± 34.1	150.9 ± 45.7	158.3 ± 45.5	142.7 ± 40.3	184.3 ± 41.43	188.9 ± 424
TG, mg/dL	134.4 ± 78.4	130.2 ± 59.6	114.2 ± 53.4	151.2 ± 81.6	169.1 ± 81.1	165.8 ± 79.4
HDL-c, mg/dL	36.9 ± 7.7	38.8 ± 12.9	45.9 ± 17.61	34.7 ± 6.5	42.6 ± 21.1	42.0 ± 9.7
VLDL-c, mg/dL	24.3 ± 11.4	26.7 ± 15.3	22.1 ± 10.0	30.1 ± 16.7	33.2 ± 15.7	33.1 ± 15.9
LDL-c, mg/dL	82.6 ± 29.2	85.6 ± 38.2	98.7 ± 43.5	77.7 ± 29.0	110.1 ± 33.15	121.6 ± 34.76
Lipid abnormalities, n (%)
Hypercholesterolemia	1 (5.3)	13 (8.1)	6 (22.2)2	0	19 (29.6)	8 (38.1)
Hypertriglyceridemia	7 (36.8)	43 (26.9)	6 (22.2)	3 (37.5)	26 (40.6)	9 (42.8)
Hypoalphalipoproteinemia	10 (52.6)	75 (46.9)	9 (33.3)	7 (87.5)	30 (46.9)	10 (47.6)
High LDL-c	1 (5.3)	14 (8.7)	5 (18.5)	0	12 (18.7)	7 (33.3)

¹E4 vs E3, P = 0.033;

²E4 vs E3, P = 0.024;

³E3 vs E2, P = 0.018;

⁴E4 vs E2, P = 0.014;

⁵E3 vs E2, P = 0.012;

⁶E4 vs E2, P = 0.005. E2: ε2ε2 + ε2ε3 + ε2ε4; E3: ε3ε3; E4: ε3ε4 + ε4ε4. TC: Total cholesterol; TG: Triglycerides; Hchol: Hypercholesterolemia; HTG: Hypertriglyceridemia; HALP: Hypoalphalipoproteinemia.