Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue

doi:10.3748/wjg.v25.i36.5530

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 28, 2019; 25(36): 5530-5542
Published online Sep 28, 2019. doi: 10.3748/wjg.v25.i36.5530

Table 2 Pathologic features of surgical resections and mutational analysis of cystic fluid and neoplastic tissue

Final diagn-osis	Pat. code	Gender	Age	Status	Sample	Proportion of mutated allele								Patholo-gical feature-s
Final diagn-osis	Pat. code	Gender	Age	Status	Sample	KRAS	GNAS	TP53	RAF1	PTPRD	CTNNB1	RNF43	POLD1	Patholo-gical feature-s
Cancer	1	F	73	No mutatio-n	CF	-	-	-	-	-	-	-	-	MCN with invasive ADK
Cancer	1	F	73	No mutatio-n	NT	-	-	-	-	-	-	-	-	MCN with invasive ADK
Cancer	9	M	72	Noncon-cordant mutatio-ns	CF	0	-	-	0	0	-	-	-	IPMN with invasive adenoca-rcinoma pT2N1
Cancer	9	M	72	Noncon-cordant mutatio-ns	NT	100	-	-	26	100	-	-	-	IPMN with invasive adenoca-rcinoma pT2N1
Cancer	10	F	60	Conc-ordant mutatio-ns	CF	5	-	-	-	-	-	-	50	IPMN with invasive adenoca-rcinoma pT3N1
Cancer	10	F	60	Conc-ordant mutatio-ns	NT	0	-	-	-	-	-	-	24	IPMN with invasive adenoca-rcinoma pT3N1
Cancer	13	M	66	Concor-dant mutatio-ns	CF	3	-	1	-	-	-	-	-	IPMN with invasive adenoca-rcinoma pT3N1
Cancer	13	M	66	Concor-dant mutatio-ns	NT	35	-	22	-	-	-	-	-	IPMN with invasive adenoca-rcinoma pT3N1
Cancer	14	M	63	Concor-dant mutatio-ns	CF	-	37	-	-	-	-	-	-	MCN with invasive ADK
Cancer	14	M	63	Concor-dant mutatio-ns	NT	-	19	-	-	-	-	-	-	MCN with invasive ADK
Cancer	15	M	83	Concor-dant mutatio-ns	CF	32	50	-	-	-	-	-	-	IPMN with focal adenoca-rcinoma pTisN0
Cancer	15	M	83	Concor-dant mutatio-ns	NT	9	19	-	-	-	-	-	-	IPMN with focal adenoca-rcinoma pTisN0
Cancer	17	F	71	Concor-dant mutatio-ns	CF	25	48	-	-	-	56	-	-	IPMN with focal adenoca-rcinoma pTisN0
Cancer	17	F	71	Concor-dant mutatio-ns	NT	21	42	-	-	-	37	-	-	IPMN with focal adenoca-rcinoma pTisN0
Cancer	18	M	82	Concor-dant mutatio-ns	CF	41	-	-	-	-	-	39	-	IPMN with focal adenoca-rcinoma pTisN0
Cancer	18	M	82	Concor-dant mutatio-ns	NT	32	-	-	-	-	-	35	-	IPMN with focal adenoca-rcinoma pTisN0
Cancer	19	F	67	Concor-dant mutatio-ns	CF	23	-	31	-	-	-	-	-	MCN with invasive ADK
Cancer	19	F	67	Concor-dant mutatio-ns	NT	0	-	18	-	-	-	-	-	MCN with invasive ADK
NO Cancer	2	M	86	No mutatio-n	CF	-	-	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	2	M	86	No mutatio-n	NT	-	-	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	3	M	75	No mutatio-n	CF	-	-	-	-	-	-	-	-	Serous cystaden-oma
NO Cancer	3	M	75	No mutatio-n	NT	-	-	-	-	-	-	-	-	Serous cystaden-oma
NO Cancer	4	F	66	No mutatio-n	CF	-	-	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	4	F	66	No mutatio-n	NT	-	-	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	8	F	81	No mutatio-n	CF	-	-	-	-	-	-	-	-	Mucinou-s cystaden-oma
NO Cancer	8	F	81	No mutatio-n	NT	-	-	-	-	-	-	-	-	Mucinou-s cystaden-oma
NO Cancer	16	M	63	No mutatio-n	CF	-	-	-	-	-	-	-	-	Cystic lymphan-gioma
NO Cancer	16	M	63	No mutatio-n	NT	-	-	-	-	-	-	-	-	Cystic lymphan-gioma
NO Cancer	6	M	71	Nonconc-ordant mutatio-ns	CF	12	31	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	6	M	71	Nonconc-ordant mutatio-ns	NT	0	0	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	5	M	74	Concor-dant mutatio-ns	CF	41	12	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	5	M	74	Concor-dant mutatio-ns	NT	31	0	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	20	M	51	Concor-dant mutatio-ns	CF	-	26	-	-	-	-	-	-	IPMN with low-grade dysplasi-a
NO Cancer	20	M	51	Concor-dant mutatio-ns	NT	-	7	-	-	-	-	-	-	IPMN with low-grade dysplasi-a

ADK: Adenocarcinoma; CF: Cystic fluid; IPMN: Intraductal papillary mucinous neoplasm; LGD: Low-grade dysplasia; MCN: Mucinous cystadenoma; NT: Neoplastic tissue; pTis: Carcinoma in situ, invasion of lamina propria.

Citation: Laquière A, Lagarde A, Napoléon B, Bourdariat R, Atkinson A, Donatelli G, Pol B, Lecomte L, Curel L, Urena-Campos R, Helbert T, Valantin V, Mithieux F, Buono JP, Grandval P, Olschwang S. Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue. World J Gastroenterol 2019; 25(36): 5530-5542
URL: https://www.wjgnet.com/1007-9327/full/v25/i36/5530.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i36.5530