Liver stiffness and serum markers for excluding high-risk varices in patients who do not meet Baveno VI criteria

Table 4 Performance of liver stiffness measurement and serum markers of liver fibrosis in predicting high-risk varices in patients with alanine aminotransferase and total bilirubin < 2 upper limit of normal

Variable	AUROC (95%CI)	P -value	Cutoffvalue	Se (%)	Sp (%)	PPV (%)	PLR	Spared gastroscopies, n = 41, (%)
LSM	0.821 (0.670-0.923)	< 0.0001	20.60	100	66.7	60.9	3.00	16/41 (39.0)
PLT	0.628 (0.464-0.774)	0.1928
Lok index	0.638 (0.473-0.782)	0.1407
MELD	0.644 (0.479-0.787)	0.1449
APRI	0.569 (0.405- 0.722)	0.4667
FIB-4	0.608 (0.444-0.757)	0.2474

APRI: Aspartate aminotransferase-to-platelet ratio index; AUROC: Area under the receiver operating characteristic curve; CI: Confidence interval; MELD: Model for End-Stage Liver Disease; PLT: Platelet; PLR: Positive likelihood ratio; PPV: Positive predictive value; Se: Sensitivity; Sp: Specificity. P < 0.05 was statistically significant.