Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors

Table 1 Tissue and circulating long non-coding RNAs with altered expression in colorectal cancer

lncRNA	Tissue	Plasma/serum	Exosome	Expression in CRC	Ref.	Potentially diagnostic marker	Prognostic role
91H	X	X	X	Up	[130,138,152]	X (comb 1)	Up – poor prognosis
ADAMTS9-AS2	X			Down	[145]		Down – poor prognosis
AFAP1-AS1	X			Up	[145,153,154]		Up - poor prognosis
AK027294	X			Up	[155]
AK123657/BX64820	X			Down	[156]		Down – poor prognosis
AK307796	X			Up	[157]
ANRIL	X			Up	[158,159]		Up – poor prognosis
ATB	X	X		Up	[122,160,161]		Up - poor prognosis
BA318C17.1	X			Down	[162]
BANCR	X	X		Down/up	[125,163,164]	X (comb 2)	Prognostic
BCAR4/HOXA-AS2	X	X	X	Up/down	[140,145]	X	Up – poor prognosis
BLACAT1	X	X		Up	[129,151,165]		Up - poor prognosis
CAHM	X			Down	[131]	X
CASC11	X			Up	[166]
CASC2	X			Down	[167]		Down - poor prognosis
CCAL	X			Up	[4]		Up - poor prognosis
CCAT1	X	X		Up	[23,96-98,116,168-170]	X	Up – poor prognosis
CCAT1-L	X			Up	[171]
CCAT2	X	X		Up	[134,172,173]	X	Prognostic
CLMAT3	X			Up	[174,175]		Up – poor prognosis
CRNDE	X	X	X	Up	[24,99,103]	X	Up – poor prognosis
CRCAL-1/AC021218.2	X			Up	[100]	X
CRCAL-2/LINC00858	X			Up	[100]	X
CRCAL-3/RP11-138J23.1	X			Up	[100]	X
CRCAL-4/RP11-453O5.2	X			Up	[100]	X
CTD903	X			Down	[176]		Down - poor prognosis
CTNNAP1	X			Down	[177]	X
DACOR1	X			Up	[54]
DANCR	X			Up	[178]		Up – poor prognosis
DQ786243	X			Up	[179]		Prognostic
E2F4 antisense	X			Up	[180]
ENST00000430471	X			Up	[181]
ENST00000455974/AC123023.1	X			Up	[111]	X	Up - poor prognosis
ENST00000465846	X			Down	[157]
FER1L4	X	X		Down	[123]		Down - poor prognosis
FEZF1-AS1	X			Up	[115,182]		Up - poor prognosis
FTX	X			Up	[183]		Up – poor prognosis
GAPLINC	X			Up	[184]		Prognostic
GAS5	X	X	X	Down	[120,185-188]		Down - poor prognosis
GHET1	X			Up	[189]
lnc-GNAT1-1		X			[119]
H19	X			Up	[94,143-145,190,191]		Up - poor prognosis
HIF1-AS1	X	X			[132]		Up - poor prognosis
HIF2PUT	X			Up	[192]
HOTAIR	X	X		Up	[87-90,116,193,194]		Up - poor prognosis
HOTAIRM1	X	X		Down	[117]		Down – poor prognosis
HOTTIP	X			Up	[195,196]		Up – poor prognosis
HULC	X	X		Up	[134,197]		Up - poor prognosis
KCNQ1OT1	X			Up	[198,199]
LINC00152 (CYTOR)	X			Up	[8,11,13]		Up – poor prognosis
LINC01133	X			Down	[200]		Down - poor prognosis
LINC01296	X			Down	[201]		Down – poor prognosis
lincRNA-p21	X	X		Down	[116,202-204]		Down – poor prognosis
Lnc34a	X			Up	[205]
lncRNA-LET/NPNT-IT1	X			Down	[206]
LNCV6_116109			X	Up	[139]	X
LNCV6_98390			X	Up	[139]	X
LNCV6_38772			X	Up	[139]	X
LNCV6_108226			X	Up	[139]	X
LNCV6_84003			X	Up	[139]	X
LNCV6_98602			X	Up	[139]	X
LOC152578		X		Up	[126]	X (comb 3)
LOC100287225	X			Down	[207,208]
LOC285194/TUSC7	X	X		Down/Up	[124,209,210]	X (comb 4)	Down - poor prognosis
Loc554202	X			Down	[211,212]		Down - poor prognosis
MALAT1	X	X		Up	[7,91-93,145,149,213,214]		Up - poor prognosis
MEG3	X	X		Down	[100,130,215-218]	X (comb 1)	Down - poor prognosis
Nbla12061		X		Up	[124]	X (comb 4)
ncNRFR	X			Up	[219]
ncRAN	X			Down	[220,221]		Down – poor prognosis
ncRuPAR	X			Down	[222]		Down – poor prognosis
NEAT1	X	X		Up	[128,223]		Up - poor prognosis
NORAD		X			[133]
NR_026817		X		Down	[125]	X (comb 2)	Prognostic
NR_029373	X	X		Down	[125]	X (comb 2)	Down – poor prognosis
NR_034119		X		Down	[125]	X (comb 2)
PANDAR	X			Up	[224]		Up - poor prognosis
PCAT-1	X			Up	[225]		Up – poor prognosis
PRNCR1	X			Up	[226,227]
PVT-1	X	X		Up	[130,145,228]	X (comb 1)	Up - poor prognosis
RP1-13P20.6	X			Down	[229]		Down - poor prognosis
RP11-462C24.1	X	X		Down/Up	[124,230,231]	X (comb 4)	Down - poor prognosis
SLC25A25-AS1	X	X		Down	[118]		Down - poor prognosis
SnaR	X				[232]
SNHG20	X			Up	[233]		Prognostic
SNHGI2	X			Up	[234]		Up - poor prognosis
Sox2ot	X			Up	[235]
SPRY4-IT1	X	X		Up	[121,236]		Up - poor prognosis
TINCR	X			Down	[100,237]
TUG1	X	X	X	Up	[101,238-240]		Up - poor prognosis
uc.388	X			Down/Up	[241,242]	X	Prognostic
uc.73a	X			Down/Up	[241,242]	X
uc002kmd.1	X			Up	[243]
UCA1	X	X	X	Up	[100,101,110,244,245]		Up - poor prognosis
UPAT	X			Up	[246]
XIST	X	X		Up	[247,248]		Prognostic
XLOC_000303		X		Up	[136]	X (comb 3)
XLOC_006844	X	X		Up	[136]	X (comb 3)
ZFAS1	X	X		Up	[19,249]		Up - poor prognosis
ZNF582-AS1	X			Down	[250]	X

The altered expression of long non-coding RNAs in colorectal cancer tissue, plasma/serum or exosomes and the potential diagnostic value are marked with X, respectively. Combined marker sets are also represented (comb 1, comb 2, comb 3 and comb 4).