Methionine adenosyltransferases in liver cancer

doi:10.3748/wjg.v25.i31.4300

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Aug 21, 2019 (publication date) through Sep 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2019; 25(31): 4300-4319
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4300

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Figure 2 SAMe synthesis reaction. MAT enzyme catalyzes the biosynthesis of SAMe from the amino acid methionine and the energy molecule ATP. The sulphur atom of methionine attacks the C5’ atom of ATP displacing the tripolyphosphate (PPPi) moiety to form SAMe. The PPPi is then hydrolyzed giving rise to pyrophosphate (PPi) and orthophosphate (Pi).

Citation: Murray B, Barbier-Torres L, Fan W, Mato JM, Lu SC. Methionine adenosyltransferases in liver cancer. World J Gastroenterol 2019; 25(31): 4300-4319
URL: https://www.wjgnet.com/1007-9327/full/v25/i31/4300.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i31.4300