Review
Copyright ©The Author(s) 2019.
World J Gastroenterol. Aug 21, 2019; 25(31): 4300-4319
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4300
Table 2 Regulatory mechanisms of human MAT genes and proteins
MAT1AMAT2AMAT2B
Transcriptional regulationGlucocorticoids (+)CpG hypomethylation (+)AP-1 (+)
C/EBP (+)Histone H4 acetylation (+)NFκB (+)
CpG hypermethylation (-)c-MYB (+)SIRT1 (+)
Histone H4 deacetylation (-)SP-1 (+)
c-MYC (-)AP-1 (+)
MAFG (-)NFκB (+)
c-MAF (-)HIF1α (+)
PPARγ (-)
PPARβ (+)
HBx (+)
CREB (+)
Post-transcriptional regulationAUF1 (-)HuR (+)HuR (+)
miR-485-3p (-)Methylated-HuR (-)miR-21-3p (+)
miR-495 (-)miR-21-3p (+)
miR-664 (-)miR-34a (+)
miR-34b (+)
Post-translational regulationPhosphorylation (-)Phosphorylation (+)Phosphorylation (+)
Nitrosylation (-)Sumoylation (+)GIT1 interaction (+)
Oxidation (-)Acetylation (-)MATα2 interaction (+)
MATβ interaction (+)