Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease?

Table 1 Lipid phenotype of patients presenting with genetic dyslipidemia or LAL-related dyslipidemia

Disease	TC	LDL	HDL	TG	Phenotype
LAL-related dyslipidemia	↑↑↑	↑↑↑	↓	↑	IIa, IIb,
Familial hypercholesterolemia	↑↑↑	↑↑↑	=/↓	=	IIa, IIb
Familial combined hyperlipidemia	↑↑	↑↑	↓	↑	IIa, IIb, IV, V
Familial hypertriglyceridemia	N/	↓	↓↓	↑↑	IV, V
Type III hyperlipidemia (dysbetalipoproteinemia)	↑↑	↓	=	↑↑	III, IV
Iperchylomicronemia	↑	↓	↓↓↓	↑↑↑	I, V
Hypoalfalipoproteinemia	N/↓	N	↓↓↓↓	N	Low HDL

LAL: Lysosomal acid lipase; LDL: Low-density lipoprotein; HDL: High-density lipoprotein.