Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study

Table 3 Univariate and multivariate analyses of risk factors for overall survival

Variable	Univariate analysis		Multivariate analysis
	P-value	OR (95%CI)	P-value	OR (95%CI)
Gender (male/female)	0.104	1.859 (0.896-3.856)
Age > 60 yr	0.895	1.090 (0.303-3.919)
Underlying liver disease
Hypertension (yes/no)	0.709	1.168 (0.517-2.638)
Diabetes (yes/no)	0.491	1.497 (0.474-4.726)
Coexisting condition
Drinking (yes/no)	0.331	0.539 (0.156-1.871)
Smoking (yes/no)	0.648	0.823 (0.356-1.902)
Platelet count at admission (< 30 × 109/L)	0.649	0.837 (0.388-1.804)
ALT (> 40 U/L)	0.061	0.510 (0.253-1.030)	0.495	0.710 (0.266-1.897)
AST (> 40 U/L)	0.057	0.500 (0.245-1.021)	0.617	0.772 (0.279-2.132)
Albumin (< 35 g/L)	0.012	2.583 (1.236-5.398)	0.737	1.158 (0.492-2.724)
Total bilirubin (> 17 μmol/L)	0.260	0.620 (0.270-1.425)
PT (> 17 s)	0.053	0.492 (0.240-1.010)	0.496	0.750 (0.328-1.715)
APTT (> 45 s)	0.907	0.955 (0.444-2.054)
INR (> 1.2)	0.371	0.668 (0.276-1.617)
Child-Pugh score	0.008	0.422 (0.222-0.800)	0.181	1.728 (0.775-3.857)
Surgical method (LS vs OS)	0.068	6.562 (0.871-49.440)	0.157	4.393 (0.566-34.110)
Intraoperative blood loss (mL)	0.131	0.999 (0.998-1.000)
Spleen volume (mm3)	0.634	1.000 (1.000-1.001)
Spleen size (mm)	0.563	1.003 (0.993-1.013)
Postoperative early aspirin (yes/no)	0.017	0.170 (0.040-0.731)	0.044	0.218 (0.049-0.960)

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PT: Prothrombin time; APTT: Activated partial thromboplatin time; INR: International normalized ratio; LS: Laparoscopic surgery; OS: Open surgery.