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Copyright ©The Author(s) 2019.
World J Gastroenterol. Jul 28, 2019; 25(28): 3753-3763
Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3753
Table 2 Diagnostic criteria for hepatic sinusoidal obstruction syndrome
HSCT-related HSOS
PAs-induced HSOS
Classical HSOS
Late onset HSOS (> 21 d after HSCT)
Criteria proposed by Gao et al[51]Nanjing criteria[16]
Modified Seattle criteria[49]Baltimore criteria[50]New EBMT criteria[6]
Presence of 2 of the following criteria within 20 d after HSCT:Presence of bilirubin ≥ 34.2 μmol/L within 21 d after HSCT and at least 2 of the following criteria:Baltimore criteria beyond 21 d1 Meeting the modified Seattle criteriaA definite history of taking herbs containing PAs
OR
Histologically proven HSOSPathological evidencePresence of the following three criteria
2 Meeting the criteria for DILI
1 Abdominal distention and/or pain in the hepatic region, hepatomegaly, and ascites;
OR
3 A history of taking PAs-containing herbs; detection of PPAs
Presence of at least 2 of the following criteria: Bilirubin ≥ 2 mg/dL (34.2 μmol/L)
2 Increased serum total bilirubin or other abnormal liver function;
1 Bilirubin ≥ 34.2 μmol/L;1 Hepatomegaly;1 Hepatomegaly
2 Hepatomegaly or right upper quadrant pain;2 Ascites;2 Ascites
3 Weight gain > 5%3 Weight gain > 5%
3 Weight gain > 2%AND hemodynamical or/and ultrasound evidence of HSOS
3 Typical contrast-enhanced CT or MRI findings
Other liver diseases were excluded