Histologic features and genomic alterations of primary colorectal adenocarcinoma predict growth patterns of liver metastasis

Figure 4 Subtypes of histologic growth pattern of primary colorectal carcinoma. A: Ordinary expanding, where the tumor gland pushes the stroma and forms a sharp dividing line at the interface; B: Mucinous expanding, where pools of tumor epithelium containing mucin pushes the stroma and forms a sharp dividing line at the interface; C: Cribriform expanding, where the tumor gland at the invasive front forms a round cribriform structure and there is a clear dividing line between the tumor and the surrounding stroma; D: Micropapillary expanding, where the tumor cells at the invasive front forms micropapillary architecture and there is a clear dividing line between the tumor and the surrounding stroma; E: Ordinary infiltrating, where tumor cells infiltrate to the stroma and connect to the original tumor mass; F: Skip infiltrating, where there is a gap (>0.5 cm) of non-neoplastic tissue between the main tumor bulk and the invasive front.