Synchronous resection of esophageal cancer and other organ malignancies: A systematic review

Table 2 Characteristics of patients undergoing simultaneous resection of esophageal and other organ neoplasms

Second primary tumor in stomach
Author	Number of cases	Age (mean)	Type of surgery			Anastomotic leaks	Perioperative deaths
			Esophagus	Stomach	Esophageal substitute
Kato et al[26]	n = 71	64	TTE (n = 70)	Non-anatomic resection (n = 46)	Stomach (n = 46)	N/A	n = 3
			THE (n = 1)	Total gastrectomy (n = 25)	Colon (n = 22)		n = 1
					Jejunum (n = 3)
Isohata et al[24]	n = 1	70	TTE (n = 1)	Non-anatomic resection (n = 1)	Stomach (n = 1)	n = 0	n = 0
Songping et al[40]	n = 1	65	TAB (n = 1)	Distal gastrectomy (n = 1)	Stomach (n = 1)	n = 0	n = 0
Kanda et al[42]	n = 1	57	TTE (n = 1)	Distal gastrectomy (n = 1)	Stomach (n = 1)	n = 1	n = 0
Zhou et al[41]	n = 1	77	TTE (n = 1)	Non-anatomic resection (n = 1)	Stomach (n = 1)	N/A	N/A
I H et al[38]	n = 4	65	TTE (n = 4)	ESD (n = 4)	Stomach (n = 4)	n = 0	n = 0
Chan et al[36]	n = 5	69	TTE (n = 5)	Non-anatomic resection (n = 5)	Stomach (n = 5)	N/A	n = 0
1Fukaya et al[37]	n = 1	69	TTE (n = 1)	Total gastrectomy (n = 1)	Colon (n = 1)	n = 12	n = 0
Second primary tumor in pancreas/ampulla of Vater
			Esophagus	Pancreas /ampullary	Esophageal substitute
Mafune et al[31]	n = 1	64	TTE (n = 1)	PD (n = 1)	Colon (n = 1)	n = 1	n = 0
Kurosaki et al[29]	n = 1	72	THE (n = 1)	PPPD (n = 1)	Stomach (n = 1)	n = 0	n = 0
Jayaprakash et al[25]	n = 1	62	TTE (n = 1)	PD (n = 1)	Jejunum (n = 1)	n = 0	n = 0
Kim et al[27]	n = 1	65	THE (n = 1)	PD (n = 1)	Jejunum (n = 1)	n = 0	n = 0
1Gyorki et al[22]	n = 1	58	TTE (n = 1)	PPPD (n = 1)	Colon (n = 1)	N/A	N/A
1Fukaya et al[37]	n = 1	69	TTE (n = 1)	PD (n = 1)	Colon (n = 1)	n = 1	n = 0
Second primary tumor in lung
			Esophagus	Lung	Esophageal substitute
Fekete et al[21]	n = 12	N/A	TTE (n = 12)	Pneumonectomy (n = 1)	Stomach (n = 12)	n = 1	n = 1
				Bilobectomy (n = 1)
				Lobectomy (n = 9)
				Segmentectomy (n = 1)
Lindeman et al[30]	n = 1	60	TTE (n = 1)	Lobectomy (n = 1)	Stomach (n = 1)	n = 0	n = 0
1Ishii et al[23]	n = 2	57	TTE (n = 2)	Segmentectomy (n = 1)	Stomach (n = 2)	n = 1	n = 0
Wang et al[39]	n = 3	65	TTE (n = 3)	Bilobectomy (n = 1)	Stomach (n = 3)	n = 0	n = 0
				Lobectomy (n = 2)
Second primary tumor in colon/rectum
			Esophagus	Colon/rectum	Esophageal substitute
Motoori et al[32]	n = 1	75	N/A	AR (n = 1)	N/A	N/A	N/A
1Akiyama et al[35]	n = 1	73	TTE (n = 1)	AR (n = 1)	Stomach (n = 1)	n = 0	n = 0
Second primary tumor in kidney
			Esophagus	Kidney	Esophageal substitute
Kobayashi et al[28]	n = 2	61	TTE (n = 2)	Nephrectomy (n = 2)	Stomach (n = 2)	n = 1	n = 0
Liano et al[20]	n = 1	64	TTE (n = 1)	Nephrectomy (n = 1)	Stomach (n = 1)	n = 0	n = 0
De Hingh et al[19]	n = 1	69	THE (n = 1)	Nephrectomy (n = 1)	Stomach (n = 1)	n = 0	n = 0
1Vilcea et al[34]	n = 1	56	TTE (n = 1)	Nephrectomy (n = 1)	Stomach (n = 1)	n = 1	n = 0
Second primary tumor in liver
			Esophagus	Liver	Esophageal substitute
Nagahama et al[33]	n = 2	75	TTE (n = 2)	Right posterior sectionectomy (n = 2)	Stomach (n = 2)	n = 0	n = 0
1Akiyama et al[35]	n = 1	73	TTE (n = 1)	Bisegmentectomy (n = 1)	Stomach (n = 1)	n = 0	n = 0

¹Patients undergoing a two-stage procedure;

²Anastomotic leak from pancreaticojejunal anastomosis. TTE: Transthoracic esophagectomy; THE: Transhiatal esophagectomy; TAB: Thoracoabdominal esophagectomy; PD: Pancreaticoduodenectomy; PPPD: Pylorus preserving pancreaticoduodenectomy; AR: Anterior resection; ESD: Endoscopic submucosal dissection.