Synchronous resection of esophageal cancer and other organ malignancies: A systematic review

Table 1 Summary of included studies

Author	Year	Number of patients	Esophageal tumor location	Esophageal tumor histology	Second primary tumor location	Second primary tumor histology
Kato et al[26]	1994	71	Upper (n = 4),	N/A	Stomach (n = 71)	Adenocarcinoma
			Middle (n = 46),
			Lower (n = 21)
Isohata et al[24]	2008	1	Double tumor (lower and middle)	Adenocarcinoma	Stomach	Adenocarcinoma
Songping et al[40]	2013	1	Middle	SCC	Stomach	Adenocarcinoma
Kanda et al[42]	2011	1	Middle	SCC	Stomach	Adenocarcinoma
Zhou et al[41]	2013	1	Lower	SCC	Stomach	Adenocarcinoma and GIST
I H et al[38]	2013	4	Middle (n = 3),	SCC	Stomach	Adenocarcinoma
			Lower (n = 1)
Chan et al[36]	2013	5	Proximal (n = 1),	SCC (n = 1),	Stomach	GIST
			Middle (n = 1),
				Adenocarcinoma (n = 4)
			Lower (n = 3)
Fukaya et al[37]	2014	1	Middle	SCC	Stomach and Ampulla of Vater	Adenocarcinoma and small cell carcinoma
Mafune et al[31]	1995	1	Lower	SCC	Ampulla of Vater	Adenocarcinoma
Kurosaki et al[29]	2000	1	Middle	SCC	Pancreatic Head	Adenocarcinoma
Jayaprakash et al[25]	2009	1	GEJ	Adenocarcinoma	Ampulla of Vater	Adenocarcinoma
Kim et al[27]	2011	1	Lower	Adenocarcinoma	Pancreatic Head	Adenocarcinoma
Gyorki et al[22]	2011	1	Middle	Adenocarcinoma	Pancreatic Head	Neuroendocrine carcinoma
Fekete et al[21]	1994	12	N/A	SCC	Lung	N/A
Lindeman et al[30]	2007	1	Middle	SCC	Lung	SCC
Ishii et al[23]	2008	2	Middle (n = 1),	SCC	Lung	Adenocarcinoma
			Lower (n = 1)
Wang et al[39]	2012	3	Middle (n = 1),	SCC	Lung	SCC (n = 1), Adenocarcinoma (n = 2)
			Lower (n = 2)
Motoori et al[32]	2001	1	Middle	SCC	Rectum	Adenocarcinoma
Akiyama et al[35]	2015	1	Middle	SCC	Colon & Liver	Adenocarcinoma and HCC
Kobayashi et al[28]	2000	2	Middle (n = 1),	SCC	Kidney	Clear cell carcinoma
			Lower (n = 1)
Liano et al[20]	2007	1	Lower	SCC	Kidney	Clear cell carcinoma
De Hingh et al[19]	2007	1	N/A	Adenocarcinoma	Kidney	Renal cell carcinoma
Vilcea et al[34]	2010	1	Middle	SCC	Kidney	Urothelial
Nagahama et al[33]	1996	2	Middle (n = 2)	SCC	Liver	HCC

N/A: Non-available; SCC: Squamous cell carcinoma; HCC: Hepatocellular carcinoma; GIST: Gastrointestinal stromal tumors.