High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis

Figure 9 Fagan nomograms used to calculate post-test probabilities based on different scenarios defined by colorectal cancer prevalence and supposed accuracy of OC-Sensor (Threshold 10 µg Hb/g faeces). A-C; These scenarios are defined by colorectal cancer (CRC) prevalence of 1%, 3% and 13% respectively and faecal immunochemical test for haemoglobin (FIT) accuracy parameters used were the pooled estimates calculated with ‘mixed cohorts’ studies; D-F; These scenarios are defined by CRC prevalence of 1%, 3% and 13% respectively and FIT accuracy parameters used were the pooled estimates calculated with ‘100% symptomatic’ studies. CRC: Colorectal cancer; FIT: Faecal immunochemical test for haemoglobin.