High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis

Figure 8 Relationship between colorectal cancer prevalence, clinical spectrum and accuracy of faecal immunochemical test for haemoglobin to rule out colorectal cancer. A: There is no correlation between colorectal cancer (CRC) prevalence and faecal immunochemical test for haemoglobin (FIT) sensitivity; B: Pooled FIT sensitivity to detect CRC cancer estimated from studies with ‘Mixed cohorts’ is significantly lower than estimated with ‘100% symptomatic’ cohorts; C: Number of missed CRC per 1000 assessed symptomatic patients with colorectal cancer calculated through Fagan nomograms under various assumptions (FIT accuracy parameters estimated with mixed cohorts or 100% symptomatic cohorts) and CRC prevalence. CRC: Colorectal cancer; FIT: Faecal immunochemical test for haemoglobin.