Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?

doi:10.3748/wjg.v24.i9.971

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 7, 2018; 24(9): 971-981
Published online Mar 7, 2018. doi: 10.3748/wjg.v24.i9.971

Table 4 Fluoroquinolone resistance rates and the distribution of resistance-mediating mutations

Genotype	Number of gastric biopsy specimens n (%)			P value¹
Genotype	All patients 165 (100)	Treatment Naïve 105 (63.6)	Previously treated 60 (36.4)	P value¹
Fluoroquinolone^S (WT)	132 (80.0)	89 (84.8)	43 (71.7)
Fluoroquinolone^R	33 (20.0)	16 (15.2)	17 (28.3)	NS
Point mutations
gyr91 D91Y	18 (54.5)	10 (62.5)	8 (47.1)	NS
gyr91 D91N	6 (18.2)	2 (12.5)	4 (23.5)	NS
gyr91 D91G	2 (6.1)	0 (0.0)	2 (11.8)	NS
gyr91 D91N + gyr91 D91G	2 (6.1)	1 (6.3)	1 (5.9)	NS
gyr91 D91N +gyr91 D91Y	2 (6.1)	1 (6.3)	1 (5.9)	NS
gyr87 N87K	1 (3.0)	1 (6.3)	0 (0.0)	NS
gyr87 N87K + gyr91 D91N + gyr91 D91G	1 (3.0)	0 (0.0)	1 (5.9)	NS
gyr87 N87K + gyr91 D91N + gyr91 D91G + gyr91 D91Y	1 (3.0)	1 (6.3)	0 (0.0)	NS

¹Treatment-naïve versus previously treated patients (Fisher’s exact test). Fluoroquinolone^S: Sensitive to fluoroquinolones; Fluoroquinolone^R: Resistant to fluoroquinolones.

Citation: Brennan DE, Dowd C, O’Morain C, McNamara D, Smith SM. Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection? World J Gastroenterol 2018; 24(9): 971-981
URL: https://www.wjgnet.com/1007-9327/full/v24/i9/971.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i9.971