Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome

Figure 4 Inhibitory effects of PA on CCh-induced contraction in the isolated colonic longitudinal smooth muscle. Mechanical recording (A to F) and cumulative log concentration-response curve (G) of CCh-induced contraction of the smooth muscle in IBS-D rats. Colonic tissues (control group [A]: n = 14, IBS-D group [B]: n = 16; ^aP < 0.05 vs control group, unpaired t test). Jejunal tissues (H) (control group [C]: n = 14, IBS-D group [D]: n = 11; ^aP < 0.05 vs control group, unpaired t test). Cumulative log concentration-response curve (I) of the effect of PA (100 µmol/L) on CCh-induced contraction of smooth muscle in IBS-D rats. Colonic tissues (IBS-D group: n = 16, PA-treated IBS-D group [F]: n = 8; ^cP < 0.05 vs group IBS-D, ^dP < 0.01 vs group IBS-D, unpaired t test). Cumulative log concentration-response curve (J) of the effect of PA (100 µmol/L) on CCh-induced contraction of the smooth muscle in control rats. Colonic tissues (control group: n = 14, PA-treated control group [E]: n = 8. ^aP < 0.05 vs control group, ^bP < 0.01 vs control group, unpaired t test). Data are expressed as mean ± SE. CCh: Carbachol, IBS-D: Irritable bowel syndrome; PA: Patchouli alcohol.