Effect of photodynamic therapy with (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt on pancreatic cancer cells in vitro and in vivo

Figure 5 Biodistribution of (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt in vivo. A: In vivo fluorescence (FL) images and quantitative evaluation of the Panc-1 tumor-bearing mice at 5, 24, and 48 h post-intraperitoneal (IP) or -intratumoral (IT) injection of (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt (YLG-1). Mice listed from left to right were respectively administered with 60, 30, and 8 mg/kg YLG-1 via IP injection and 8 mg/kg YLG-1 by IT injection. B: In vivo FL image and quantitative analysis of mice at 5 h after IT injection with 30 or 8 mg/kg YLG-1. C: In vivo FL images and quantitative analysis of mice at 0, 1, 2, and 4 h post-IT injection of 8 mg/kg YLG-1. The FL intensity of YLG-1 in the tumor site was quantified using the same color scale (min = 6.35e⁸ and max = 6.31e⁹). The data are shown as the mean ± SD (n = 3). ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001 vs the corresponding IT injection group. YLG-1: (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt; FL: Fluorescence; IP: Intraperitoneal; IT: Intratumoral.