Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death

Table 3 Univariate analysis for the factors associated with posttransplant metabolic syndrome

Variable	OR (95%CI)	P value
Age	1.26 (0.48-3.31)	0.642
Male	1.25 (0.34-4.64)	0.735
Smoking	1.33 (0.45-3.92)	0.605
Alcohol	2.44 (0.83-7.13)	0.104
HBV	0.92 (0.34-2.47)	0.865
HCV	0.43 (2.25-13.6)	0.408
BMI	7.69 (1.75-33.8)	0.007
Pre-LT diabetes mellitus	2.19 (0.64-7.55)	0.214
Pre-LT hypertension	1.62 (0.17-15.3)	0.674
Pre-LT dyslipidemia	2.17 (0.27-17.5)	0.469
Donor age	2.42 (0.67-8.74)	0.178
Donor BMI	1.91 (0.37-9.90)	0.443
WIT	1.21 (1.04-1.41)	0.014
CIT	0.95 (0.69-1.31)	0.741
Steroid-free protocol for HCC	0.35 (0.10-1.24)	0.065
Tacrolimus use ≥ 24 mo	1.77 (0.39-4.01)	0.591
Cyclosporine use ≥ 24 mo	1.30 (0.50-3.40)	0.591
MMF use ≥ 24 mo	1.05 (0.39-2.83)	0.920
Acute graft rejection	1.69 (0.43-6.61)	0.450
Biliary complication	0.48 (0.17-2.28)	0.467
Acute kidney injury	4.72 (1.60-14.0)	0.005
Hyperuricemia	6.95 (2.54-19.0)	< 0.001

OR: Odds ratio; CI: Confidence interval; HBV: Hepatitis B virus; HCV: Hepatitis C virus; BMI, Body mass index; WIT: Warm ischemia time; CIT; Cold ischemia time; LT: Liver transplantation; HCC: Hepatocellular carcinoma; MMF: Mycophenolate mofetil.