Ubiquitin-like modifier activating enzyme 2 promotes cell migration and invasion through Wnt/β-catenin signaling in gastric cancer

Figure 3 Ubiquitin-like modifier activating enzyme 2 promotes cell growth and colony formation in gastric cancer. A: MTT assay showed that knock-down of Uba2 (siUba2) inhibited growth of BGC-823 cells, and over-expression of Uba2 promoted growth of SGC-7901 cells; B: Colony formation assay showed down-regulation of colony number in BGC-823 siUba2 cells and up-regulation in SGC-7901 cells with Uba2 over-expression. Data are shown as mean ± SD from three independent experiments. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs Control; ^dP < 0.05, ^eP < 0.01 vs EV. EV: Empty vector; Uba2: Ubiquitin-like modifier activating enzyme 2.