Retrospective Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Oct 28, 2018; 24(40): 4596-4605
Published online Oct 28, 2018. doi: 10.3748/wjg.v24.i40.4596
Table 3 Adverse events of furazolidone- and amoxicillin-based quadruple therapy (n = 859) n (%)
Adverse eventNumberSevereImpact on treatment
Abdominal discomfort39 (4.5)-2 stopped prior to completion (10, 12 d)
Dizziness11 (1.3)2 (0.2)4 stopped prior to completion (7, 10, 10, 12 d); 1 experienced dizziness after drinking alcohol and stopped prior to completion (10 d); 1 took 50% medicine
Nausea (with/without vomiting)20 (2.3)-1 took 75% medicine
Fatigue11 (1.3)1 (0.1)1 stopped prior to completion (12 d); 1 changed to traditional Chinese medicine during therapy (7 d)
Anorexia13 (1.5)-1 took 80% medicine
Skin rash/pruritus18 (2.1)3 (0.4)4 stopped prior to completion (4, 7, 10, 11 d); 2 changed to other regimens during therapy (2, 10 d); 1 took half of amoxicillin and all other drugs
Fever2 (0.2)2 (0.2)2 stopped prior to completion (7, 9 d)
Diarrhea9 (1.1)1 (0.1)1 stopped prior to completion (less than 7 d)
Constipation3 (0.4)--
Flatulence2 (0.2)--
Muscle pain or spasm (shoulder/back)3 (0.4)--
Acid regurgitation1 (0.1)--
Abdominal pain4 (0.5)1 (0.1)2 stopped prior to completion (7,10 d)
Weight loss3 (0.4)--
Bitter taste/dry throat2 (0.2)-1 took 75% medicine
Belching1 (0.1)--
Chest congestion1 (0.1)--
Heartburn1 (0.1)--
Total144 (16.8)10 (1.2)24 (2.8)