Barrett’s esophagus with high grade dysplasia is associated with non-esophageal cancer

Table 4 Univariate and multivariable Cox regression for the prediction of any cancer

n = 386 (including EAC and IMC)	HR (95%CI)	Adjusted HR (95%CI)
Age at study inclusion1	1.09 (0.99-1.20)	1.08 (0.97-1.21)
Gender - male	2.29 (0.79-6.67)
Number of endoscopies per patient	1.11 (0.96-1.29)	0.99 (0.82-1.21)
Presence of endoscopic abnormalities	2.27 (0.95-5.44)
Circumferential extent of BE (cm)	1.10 (0.96-1.26)
Maximal extent of BE (cm)	1.12 (1.008-1.24)a	1.13 (1.000-1.27)
Ultra-short segment (BE < 1cm)	1
Short segment (1 cm ≤ BE < 3 cm)	0.97 (0.11-8.30)
Long segment (BE ≥ 3 cm)	1.77 (0.23-13.34)
Pre-study cancer history	2.15 (0.86-5.39)
HGD vs non-HGD	6.33 (2.37-16.91)b	4.28 (1.17-15.76)a

^aP < 0.05,

^bP < 0.01.

¹For a 3-year increase. BE: Barrett’s esophagus; EAC: Esophageal adenocarcinoma; IMC: Intramucosal carcinoma; HGD: High grade dysplasia; Non-HGD: Low grade or without dysplasia.