Barrett’s esophagus with high grade dysplasia is associated with non-esophageal cancer

Table 3 Univariate and multivariable Cox regression for the prediction of non- Barrett’s esophagus cancers

n = 379 (excluding EAC and IMC)	HR (95%CI)	Adjusted HR (95%CI)
Age at study inclusion1	1.11 (0.99-1.24)	1.07 (0.95-1.21)
Gender - male	2.19 (0.63-7.55)
Number of endoscopies per patient	0.82 (0.59-1.12)	0.72 (0.50-1.03)
Presence of endoscopic abnormalities	1.19 (0.34-4.09)
Circumferential extent of BE (cm)	0.99 (0.79-1.26)
Maximal extent of BE (cm)	1.06 (0.92-1.23)
Ultra-short segment (BE < 1 cm)	1
Short segment (1 cm ≤ BE < 3 cm)	0.96 (0.11-8.24)
Long segment (BE ≥ 3 cm)	0.99 (0.13-7.85)
Pre-study cancer history	2.58 (0.92-7.25)	2.12 (0.73-6.17)
HGD vs non-HGD	3.40 (0.78-14.84)	8.32 (1.35-51.33)a

^aP < 0.05;

¹For a 3-year increase. BE: Barrett’s esophagus; HGD: High grade dysplasia; Non-HGD: Low grade or without dysplasia; EAC: Esophageal adenocarcinoma; IMC: Intramucosal carcinoma.