Barrett’s esophagus with high grade dysplasia is associated with non-esophageal cancer

Table 1 Demographic, endoscopic and histologic characteristics of the study population

Patient data	All sample (n = 386)	HGD (n = 12)	Non-HGD (n = 367)
Age at study inclusion	60.0 (13.1) [61.1, 18.4-89.6]	66.3 (12.8) [66.6, 42.4-85.8]	59.8 (13.2) [60.6, 18.4-89.6]
Gender - male	268 (69.43)	9 (75)	253 (68.94)
Number of endoscopies per patient	2.5 (2.0) [2, 1-17]	6.6 (2.6) [7, 3-11]	2.4 (1.7) [2, 1-10]b
Patients with multiple endoscopies	245 (63.47%)	12 (100)	227 (61.9)a
Circumferential extent of BE (cm)	3.3 (3.3) [2, 0-19]	4.5 (2.92) [4.5, 1-11]	3.2 (3.23) [2, 0-19]
Maximal extent of BE (cm)	4.4 (3.2) [3, 0.2-20]	6.0 (3.22) [6, 2-14]	4.25 (3.17) [3, 0.2-20]a
Presence of endoscopic abnormalities	56 (14.51)	8 (66.67)	44 (11.99)b
Ultra-short BE segment (BE < 1 cm)	28 (7.43)	0 (0)	28 (7.8)
Short BE segment (1 cm ≤ BE < 3 cm)	124 (32.89)	2 (18.18)	122 (33.98)
Long BE segment (BE ≥ 3 cm)	225 (59.68)	9 (81.82)	209 (58.22)
Worst degree of dysplasia
Esophageal adenocarcinoma	6 (1.6)
Intramucosal carcinoma	1 (0.3)
High grade dysplasia	12 (3.1)
Low grade dysplasia	19 (4.9)

Continuous variables were presented as mean (SD) and [median, range]. Categorical variables are presented as n (%). Statistical difference refers to the HGD and non-HGD groups.

^aP < 0.01;

^bP < 0.001. BE: Barrett’s esophagus; HGD: High grade dysplasia; Non-HGD: Low grade or without dysplasia.