Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats

Figure 12 Caspase-8 expression in the gastric mucosa of rats with acetic acid-induced gastric ulcers treated with oral administration of vehicle, lansoprazole, or hydroalcoholic extract from the leaves of Eugenia punicifolia for 14 d. The data represent relative expression of caspase-8 normalized to the expression of housekeeping genes (actin). The results represent mean ± standard error of the mean for each group (n = 6). Statistical significance was determined using one-way ANOVA followed by Dunnett's test or Student’s t-test. ^aP < 0.05 and ^bP < 0.01 for lansoprazole and HEEP in intact females vs males. ^cP < 0.01 and ^dP < 0.001 for vehicle, lansoprazole, and HEEP in intact vs ovariectomized females. HEEP: Hydroalcoholic extract from the leaves of Eugenia punicifolia.