Adiponectin affects the mechanical responses in strips from the mouse gastric fundus

Figure 1 Effects of adiponectin on the neurally-induced contractile responses in strips from the mouse gastric fundus. A: Typical tracing showing the contractile responses to EFS (left hand panel). ADPN (20 nmol/L) decreases the amplitude of the neurally-induced contractile responses (right hand panel); B: Bar charts showing the influence of ADPN (20 nmol/L) on the mean amplitude of the EFS-induced contractile responses in the absence (left hand panel) and in the presence (right hand panel) of L-NNA (200 μmol/L). Note that, in the presence of L-NNA, ADPN no longer decreases the amplitude of the neurally-induced excitatory responses in the whole range of stimulation frequency employed. Amplitude of contractile responses is expressed as percentage of the muscular contraction evoked by 2 μmol/L methacholine, assumed as 100%. All values are means ± SE of 6 strips from 3 mice. ^aP < 0.05 vs the control; ^bP < 0.05 and P > 0.05 vs the control and vs L-NNA, respectively (Student's t-test plus ANOVA and Newman-Keuls post-test). ADPN: Adiponectin; L-NNA: L-N^G-nitro arginine.