Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer

Table 3 Univariate analysis of the correlation between clinicopathological parameters and survival of patients with gastric cancer

Clinicopathological parameters	Three-year cumulative survival rate	Log-rank test	P value
Gender
Male	75.4	0.395	0.53
Female	71.4
Age (yr)
> 60	75.4	0.163	0.686
≤ 60	73.8
Tumor size (cm)
> 5	68.3	0.988	0.32
≤ 5	79.3
Location of tumor
Lower 1/3	78.2	3.438	0.329
Middle 1/3	83.6
Upper 1/3	63.3
More than 1/3	86.7
Borrmann type
I + II	76.9	0.373	0.541
III + IV	74
Degree of differentiation
Well/moderate	75.5	0.111	0.739
Poor and not	74.2
Histological type
Papillary	70	4.386	0.223
Tubular	85.6
Mucinous	70
Signet-ring cell	69.1
Depth of invasion
T1 + T2	91.7	4.95	0.026
T3 + T4	71.7
Lymph node metastasis
Negative	95	4.629	0.031
Positive	71.2
TNM stage
I + II	92.3	11.424	0.001
III + IV	66.3
Distant metastasis
Negative	76.7	8.015	0.005
Positive	42.9
CDK5RAP3 expression
Low	71.1	5.168	0.023
High	90.8
DDRGK1 expression
Low	67.7	5.971	0.015
High	91.9
CDK5RAP3/DDRGK1 expression
CDK5RAP3 and/or DDRGK1 high	90.1	10.415	0.001
CDK5RAP3 and DDRGK1 low	64.2