Secondary endoscopic submucosal dissection for locally recurrent or incompletely resected gastric neoplasms

Table 3 Clinicopathologic characteristics according to surgical strategy

Characteristics	Early salvage ESD (n = 6, %)	Late salvage ESD (n = 8, %)	Late secondary ESD (n = 14, %)	P value
Gender				0. 909
Male	4 (66.7)	5 (62.5)	10 (71.4)
Female	2 (33.3)	3 (37.5)	4 (28.6)
Age [yr, mean (SD)]	65.4 (10.8)	61.6 (7.3)	63.8 (9.9)	0.749
Lesion location				0.255
Upper	2 (33.3)	0 (0.0)	1 (7.1)
Middle	2 (33.3)	4 (50.0)	9 (64.3)
Lower	2 (33.3)	4 (50.0)	4 (28.6)
Multiplicity	0 (0.0)	1 (12.5)	1 (7.1)	0.668
Lesion size [mm, mean (SD)]	19.8 (22.4)	13.6 (10.9)	16.4 (9.8)	0.701
Initial method				0.341
EMR	0 (0.0)	0 (0.0)	2 (14.3)
ESD	6 (100.0)	8 (100.0)	12 (85.7)
Macroscopic type				0.014
Elevated	0 (0.0)	0 (0.0)	7 (50.0)
Flat	4 (66.7)	2 (25.0)	3 (21.4)
Depressed	2 (33.3)	6 (75.0)	4 (28.6)
WHO classification				0.081
Low grade dysplasia	2 (33.3)	3 (37.5)	3 (21.4)
High grade dysplasia	0 (0.0)	1 (12.5)	3 (21.4)
Well differentiated	1 (16.7)	0 (0.0)	3 (21.4)
Moderately differentiated	1 (16.7)	4 (50.0)	2 (14.3)
Poorly differentiated	0 (0.0)	0 (0.0)	3 (21.4)
Signet ring cell carcinoma	0 (0.0)	0 (0.0)	0 (0.0)
No residual lesion	2 (33.3)	0 (0.0)	0 (0.0)
Depth of invasion				0.090
Dysplasia	2 (33.3)	4 (50.0)	6 (42.9)
Mucosal cancer	2 (33.3)	4 (50.0)	8 (57.1)
Submucosal cancer	0 (0.0)	0 (0.0)	0 (0.0)
No residual lesion	2 (33.3)	0 (0.0)	0 (0.0)
LVI				1.000
No	6 (100.0)	8 (100.0)	14 (100.0)
Yes	0 (0.0)	0 (0.0)	0 (0.0)
Lateral margin				0.341
Negative	6 (100.0)	8 (100.0)	12 (85.7)
Positive	0 (0.0)	0 (0.0)	2 (14.3)
Vertical margin				0.617
Negative	6 (100.0)	8 (100.0)	13 (92.9)
Positive	0 (0.0)	0 (0.0)	1 (7.1)

EMR: Endoscopic mucosal resection; ESD: Endoscopic submucosal dissection; LVI: Lymphovascular invasion.