Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis

Table 4 Guidance statements about lifestyle interventions

	EASL	NICE	Asia-Pacific	AISF	AASLD
Dietary restrictions	500-1000 kcal deficit; weight loss of 500-1000 g/wk with a 7%-10% total weight loss	Main recommendations on diet of NICE’s obesity and preventing excess weight gain guidelines	500-1000 kcal deficit	1200-1600 kcal/d; fat-low (< 30% of total calories); carbohydrate-low (< 50% of total calories)	500-1000 kcal deficit
Physical activity	Aerobic and resistance training (150-200 min/wk in 3-5 sessions)	Main recommendation of on physical activity of NICE’s obesity and preventing excess weight gain guidelines	Aerobic and resistance training	Aerobic and resistance training	Aerobic and resistance training (> 150 min/wk)
Gold standard diet	Low-to-moderate fat and moderate-to-high carbohydrate intake	No specific suggestions	All, excluding very low-calorie diets	Mediterranean diet	No specific suggestions
	Low-carbohydrate ketogenic diets or high-protein
	Mediterranean diet

EASL: European Association for the Study of the Liver; NICE: National Institute for Health and Care Excellence; AISF: Italian Association for the Study of the Liver; AASLD: American Association for the Study of Liver Diseases.