MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

doi:10.3748/wjg.v24.i27.2949

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2018; 24(27): 2949-2973
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949

Table 7 miRNA therapeutics investigated in animal models of colorectal cancer

miRNA	Animal model	Restoring or suppressing miRNA function	Therapeutic outcome	Ref.
miR-34a	Transgenic mice	Restoring	Anti-tumor	[126]
miR-135b	Xenotranplantation of tumor-derived organoids to mice	Suppression (antisense)	Anti-tumor	[129]
miR-143	Mice xenograft	Restoring	Anti-tumor	[132]
miR-145	Mice xenograft	Restoring	Negative effect	[132]
miR-4689	Mice xenograft	Restoring (mimic)	Anti-tumor	[135]

Citation: To KK, Tong CW, Wu M, Cho WC. MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside. World J Gastroenterol 2018; 24(27): 2949-2973
URL: https://www.wjgnet.com/1007-9327/full/v24/i27/2949.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i27.2949