MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

Table 6 A list of representative miRNAs involved in drug resistance to colorectal cancer therapy

miRNA	Drug(s) affected	Known molecular target(s) in CRC	Ref.
Overexpression of miRNA causing drug resistance to conventional chemotherapeutic drugs
Let-7g	S-1 (Tegafur/gimeracil/oteracil)	Cyclin D, c-myc, E2F, RAS	[229]
miR-10b	5-FU	BIM	[230]
miR-19b	5-FU	MYBL2	[231]
miR-20a	5-FU, oxaliplatin	BNIP2	[170]
miR-21	5-FU	hMSH2 and hMSH6	[120]
miR-23a	5-FU	APAF-1	[149]
miR-31	5-FU	-	[232]
miR-140	5-FU	HDAC4	[233]
miR-148a	5-FU, oxaliplatin	-	[92]
miR-181b	S-1, 5-FU	Cyclin D, c-myc, E2F, RAS	[229]
miR-192/miR-215	5-FU	DHFR	[234,235]
miR-195	5-FU	WEE1	[236]
miR-203	Oxaliplatin	ATM	[154]
miR-224	5-FU	-	[237]
miR-520g	5-FU, oxaliplatin	p21	[238]
miR-587	5-FU	PPP2R1B	[151]
miR-625-3p	Oxaliplatin	-	[94]
Downregulation of miRNA causing drug resistance to conventional chemotherapeutic drugs
miR-34a	5-FU, oxaliplatin	SIRT1, KIT, LDHA, TGF-β, SMAD4	[239-241]
miR-139-5p	5-FU	NOTCH-1	[242]
miR-153	Oxaliplatin	FOXO3	[243]
miR-194	Oxaliplatin, irinotecan	HMGA2	[244]
miR-200 family	5-FU	EMT-related genes	[245]
miR-200b-3p	Oxaliplatin	PRDX2	[246]
miR-203	5-FU	TYMS	[247]
miR-218	FOLFOX	EZH2	[248]
miR-761	5-FU	FOXM1	[249]
miR-1915	Oxaliplatin	BCL2	[155]
miR-141/miR-200c	Oxaliplatin	ZEB1	[250]
miR-18a*/miR-4802	5-FU, capecitabine	ATG7, ULK1	[251]
Overexpression of miRNA causing drug resistance to molecular targeted drugs
miR-31	Cetuximab	-	[252]
miR-126	Bevacizumab	VEGF	[104]
miR-100/miR-125b	Cetuximab	Wnt/β-catenin negative regulators	[253]
Downregulation of miRNA causing drug resistance to molecular targeted drugs
Let-7 family	Cetuximab, panitumumab	KRAS	[115,223]
miR-7	Cetuximab	EGFR, ERK1/2, AKT	[97]

EGFR: Epidermal growth factor receptor; CRC: Colorectal cancer.