Feasibility of using marginal liver grafts in living donor liver transplantation

Table 6 Remedies when using ABO- incompatible on living donor liver transplantation

Ref.	n	Immunosuppression strategy	Remedies	Conclusion	Study type
Kawagishi et al[89] (2009)	105	TAC + MP + AZ	Rituximab	ABO-incompatible LDLT can be feasible used if humoral rejection are overcome	RS
Yoon et al[90] (2018)	918	TAC + MP + steroids	Rituximab and PE	ABO-incompatible LDLT is a feasible option under remedies	RS
Sakai et al[91] (2017)	20	TAC+ MP	Rituximab and PE	FCGR SNPs influence the effect of rituximab on B-cells	PS
Egawa et al[92] (2017)	33	TAC	Rituximab, PE, local infusion, splenectomy and immunoglobulins	Only rituximab dose is a significantly favorable factor for AMR	RS
Ikegami et al[93] (2007)	1	TAC + MP + steroids	Rituximab and PE	Rituximab and plasma exchanges seemed ineffective	CR
Ikegami et al[94] (2009)	7	TAC + MP + steroids	Rituximab, IVIG, and PE	Rituximab, IVIG, and PE seems to be a safe treatment	RS
Usui et al[95] (2007)	73	TAC + MP + steroids	Rituximab, PE and splenectomy	Bone suppression is a big challenge when using rituximab	RS
Chen et al[96] (2017)	2	TAC + MP + steroids	Basiliximab combine with splenectomy	ABO-i LDLT with splenectomy is undoubtedly life-saving	CR
Uchiyama et al[97] (2011)	15	TAC + MP + steroids	Rituximab and PE	Isoagglutinin mediated-rejection should be more concerned	RS
Soin et al[98] (2014)	3	TAC + MP + steroids	Rituximab and PE	ABO-incompatible LDLT is a feasible option under remedies	CR
Rummler et al[99] (2017)	10	TAC + MP + steroids	PE	Immunosuppression only combining with PE is feasible	RS
Kim et al[100] (2016)	182	TAC + MP + steroids	Rituximab, IVIG, and PE	ABO-incompatible LDLT can be safely performed under remedies	RS
Kim et al[101] (2013)	22	TAC + MP + steroids	Rituximab and PE	ABO-incompatible LDLT can be safely performed under remedies	RS
Kawagishi et al[102] (2005)	3	TAC + MP + steroids	Rituximab and PE	ABO-incompatible LDLT can be safely performed under remedies	CR
Kim et al[103] (2017)	43	TAC + MP + steroids	Rituximab and IVIG	A simplified protocol using rituximab and IVIG for ABO-I LDLT is safe	RS
Yoshizawa et al[104] (2005)	8	TAC + MP + cyclophosphamide	Rituximab and PGE1 infusion	Rituximab prophylaxis and HA infusion therapy is feasible	RS
Egawa et al[105] (2008)	118	TAC + steroids	Methylprednisolone and PGE1 infusion	Recipients with preexisting high effector CD8 T- cells are unfavorable candidates for ABO-I LDLT	RS
Yamamoto et al[106] (2018)	40	TAC + MP + steroids	Rituximab monotherapy	Rituximab monotherapy is feasible	RS

LDLT: Living donor liver transplantation; CR: Case report; RS: Retrospective study; SNPs: Single-nucleotide polymorphisms.