INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

Table 3 INT-767 and obeticholic acid improve quantitative liver histopathology in ob/ob-NASH mice

Treatment	Lipid (steatosis)		Galectin-3 (inflammation)		Collagen 1a1 (fibrosis)
	% fractional area
	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Vehicle (n = 11)	33.0 ± 0.9	30.4 ± 0.9	5.7 ± 0.5	7.8 ± 0.5	1.2 ± 0.3	12.1 ± 0.4
OCA 10 mg/kg (n = 12)	33.4 ± 0.8	31.8 ± 0.4	5.5 ± 0.3	5.0 ± 0.2a	0.9 ± 0.1	9.0 ± 0.6a
OCA 30 mg/kg (n = 11)	32.2 ± 1.1	22.7 ± 1.0a	5.5 ± 0.4	4.0 ± 0.4a	1.2 ± 0.2	8.0 ± 0.7a
INT-767 3.0 mg/kg (n = 12)	33.0 ± 0.9	29.4 ± 1.3a	5.6 ± 0.5	5.4 ± 0.2a	1.2 ± 0.2	8.5 ± 0.6a
INT-767 10 mg/kg (n = 11)	33.7 ± 0.8	12.5 ± 1.5a	5.6 ± 0.3	2.9 ± 0.1a	0.9 ± 0.2	5.0 ± 0.3a

Fractional area (mean ± SE) at the end of study;

^aP <0.05 vs vehicle (two-way ANOVA, Bonferroni’s post-hoc test).