Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

Figure 4 Sliding window of the coded the core and X protein amino acid sequence (aa 1-79). Each point on the graph is the result of the mean information content (IC, bits) between windows of 10-aa size with displacement between them in 1-aa steps. The purple line represents the mean IC from the multiple alignments of all haplotypes (in abundance > 0.25%) in the quasispecies (QS) of all patients (n = 330), whereas the blue line shows the mean IC obtained from the multiple alignments of the consensus obtained for each patient (n = 27).