Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals

Table 1 Demographic and clinical characteristics of the chronic hepatitis C patients prior to direct-acting antivirals treatment and after achieving sustained virological response 12 n (%)

	Prior to DAA treatment (baseline)	Post-SVR 12	P1 value
Demographics
Male	49 (48)	49 (48)	NS
Age (yr, mean ± SD)	60.3 ± 10.7	60.3 ± 10.7	NS
White	37 (37)	37 (37)	NS
Hispanic	26 (26)	26 (26)	NS
African American	13 (13)	13 (13)	NS
Asian	7 (7)	7 (7)	NS
Other	2 (2)	2 (2)	NS
Declined	16 (15)	16 (15)	NS
Clinical
Hypertension	45 (43)	45 (43)	NS
Type 2 diabetes	13 (12.3)	13 (12.3)	NS
Dyslipidemia	8 (7.5)	8 (7.5)	NS
Anthropometric (mean ± SD)
Body mass index (kg/m2)	27.6 ± 6.9	27.5 ± 6.9	NS
Weight (Lbs.)	174.9 ± 46.9	172.7 ± 44.5	NS
Laboratory panel (mean ± SD)
HCV vial load log10 IU/mL	6.2 ± 0.9	0.0 ± 0.0	< 0.0001
HCV genotype
Genotype 1	86 (85)
Genotype 2	15 (14)
Genotype 4	1 (1)
AST (U/L)	51.8 ± 41.1	21.5 ± 8.0	< 0.0001
ALT (U/L)	63.1 ± 62.6	17.8 ± 12.3	< 0.0001
Alkaline phosphatase (U/L)	77.5 ± 34.0	71.0 ± 24.3	0.004
Albumin (g/dL)	4.3 ± 0.4	4.4 ± 0.4	NS
Bilirubin, total (mg/dL)	0.6 ± 0.2	0.6 ± 0.3	NS
Fasting glucose (mg/dL)	99.1 ± 30.1	102.1 ± 23.5	NS
FibroScan (mean ± SD)
Fibrosis Score (kPa)	7.4 ± 1.9	6.1 ± 3.6	0.013
IQR (%)	12.6 ± 4.9	12.3 ± 5.5	NS

¹P values (2-sided) determined from either a Fisher’s exact test for categorical variables or t-test for continuous variables. DAA: Direct-acting antivirals; SVR: Sustained virological response; HCV: Hepatitis C virus; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; IQR: Interquartile range.