Epidemiological features of chronic hepatitis C infection caused by remunerated blood donors: A nearly 27-year period survey

Table 3 Demographic and clinical characteristics of cirrhosis by hepatitis C virus infection in remunerated blood donors and multiple logistic regression analysis of factors associated with cirrhosis

	Cirrhosis by HCV, n = 161	CHC, n = 431	P value	Multivariate4
				OR	95%CI	Wald	P value
Age in yr	58.4 ± 13.2	56.5 ± 9.4	< 0.0011	2.143	0.553-6.453	4.543	0.002
≥ 40, < 50	41 (25.43)	80 (18.6)	0.0342	1
≥ 50, < 60	82 (50.9)	270 (62.6)		2.443	0.242-7.345	1.423	0.065
≥ 60	38 (23.6)	81 (18.8)		3.223	0.124-14.344	3.153	0.021
Sex
Male	75 (46.6)	202 (46.9)	0.9512	1
Female	86 (53.4)	229 (53.1)		1.223	0.112-6.765	0.653	0.445
Alcohol consumption
Never	97 (60.2)	344 (79.8)	< 0.0012	1
Occasional	40 (24.8)	55 (12.8)		0.879	0.647-2.654	2.753	0.152
Often	24 (14.9)	32 (7.4)		1.004	0.875-1.744	3.057	0.005
BMI	24.12 ± 2.32	25.45 ± 3.22	0.3531	0.647	0.465-1.632	4.135	0.432
< 25	78 (48.4)	200 (46.4)	0.1082	1
≥ 25, < 28	68 (42.2)	162 (37.6)		1.242	0.574-1.735	0.536	0.438
≥ 28	15 (9.3)	69 (16)		0.665	0.426-1.645	0.476	0.537
HOMA-IR	1.53 ± 0.48	1.51 ± 0.52	0.556	0.023	0.772-1.423	0.365	0.221
PLT as × 109/L	147.3 ± 55.7	176.3 ± 84.2	< 0.0011	1.314	0.022-1.463	3.647	0.013
ALB in g/L	42.3 ± 3.5	43.3 ± 4.5	0.5131	0.864	0.707-1.364	1.557	0.675
ALT in U/L	67.4 ± 26.5	62.6 ± 25.4	0.1131	1.643	0.463-1.755	0.634	0.247
AST in U/L	53.5 ± 27.4	54.5 ± 22.6	0.2011	1.425	0.428-1.254	0.546	0.664
SMA
Negative	144 (89.4)	373 (86.5)	0.3462	1
Positive	17 (10.6)	58 (13.5)		0.526	0.537-1.843	1.034	0.536
ANA
Negative	130 (80.7)	347 (80.5)	0.9451	1
Positive	31 (19.3)	84 (19.5)		2.123	0.132-5.563	0.843	0.246
IgG
Normal	60 (37.3)	205 (47.6)	0.0252	1
Elevated	101 (62.7)	226 (52.4)		1.352	0.663-12.267	3.537	0.012
HCV RNA in LgIU/mL	7.12 ± 2.43	6.73 ± 2.533	0.0671	0.657	0.536-1.523	0.863	0.536
≥ 3, < 5	22 (13.7)	51 (11.8)	0.5462	1
≥ 5	139 (86.3)	380 (88.2)		1.325	0.972-1.445	0.143	0.782
Genotype
I	152 (94.4)	390 (90.5)	0.3102	1
II	8 (5.0)	37 (8.6)		0.753	1.003-1.664	0.623	0.242
III	1 (0.6)	4 (0.9)		1.862	1.182-1.635	0.845	0.118
Blood donated frequency times	8.67 ± 5.43	8.42 ± 6.25	0.1071	1.536	0.874-2.154	0.923	0.101
< 5	36 (22.4)	103 (23.9)	0.6982	1
< 10, ≥ 5	66 (41.0)	186 (43.2)		0.354	0.274-1.203	0.991	0.783
≥ 10	59 (36.6)	142 (32.9)		1.024	0.154-2.163	0.332	0.224
Refused donated by elevated ALT
No	94 (58.4)	243 (56.4)	0.6612	1
Yes	67 (41.6)	188 (43.6)		0.012	0.037-1.002	0.682	0.563

Data are presented as n (%). Alcohol consumption: Often, the ethanol intake per week was more than 140 g in men (70 g in women) in the past 12 mo; Occasional, the ethanol intake per week was less than 140 g in men (70 g in women) in the past 12 mo.

¹One-way analysis;

²Pearson’s chi-square; ³Fisher’s exact test;

⁴Binary logistic regression. ALB: Albumin; ALT: Alanine aminotransferase; ANA: Antinuclear antibody; AST: Aspirate aminotransferase; BMI: Body mass index; LSM: Liver stiffness measurement; SMA: Smooth muscle actin.