Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats

Figure 7 Photomicrographs of colon. HC: Healthy control showing normal architecture of colon mucosa; DC: Disease control showing severe haemorrhage in submucosa with infiltration of inflammatory cells; MPA: MPA showing mild infiltration of inflammatory cells and mild degeneration of epithelium lining; MMF: Showing mild infiltration of inflammatory cells and mild degeneration of epithelium lining; MGLS: Prodrug of MPA and D-glucosamine; MGAS: Prodrug of MPA and D-galactosamine showing mild infiltration of inflammatory cells; GL: D-glucosamine showing mild infiltration of inflammatory cells; GA: D-galactosamine showing mild infiltration of inflammatory cells; MPA + GL: Physical mixture of D-glucosamine and MPA showing mild infiltration of inflammatory cells; MPA + GA: Physical mixture of D-galactosamine and MPA showing mild infiltration of inflammatory cells and mild degeneration of epithelium lining.