Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells

doi:10.3748/wjg.v24.i10.1072

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2018; 24(10): 1072-1083
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1072

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Figure 4 Effect of temperature and cisplatin (IC₅₀) combinations on cancer cell viability. The increase of temperature had no significant additional effect on cancer cell viability with the exception of extreme hyperthermia (44 °C-45 °C). Peaks of enhanced viability were observed in AGS and T3M4 cells at temperatures of 42 °C and 43 °C. Data are equalized to control (untreated cells) as 100% and shown in percentages. Dashed line shows IC₅₀.

Citation: Cesna V, Sukovas A, Jasukaitiene A, Naginiene R, Barauskas G, Dambrauskas Z, Paskauskas S, Gulbinas A. Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells. World J Gastroenterol 2018; 24(10): 1072-1083
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1072.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1072