Colonic lesion characterization in inflammatory bowel disease: A systematic review and meta-analysis

Table 3 Accuracy of the different technologies

Analysis groups	No. of studies	Pooled estimates (95%CI)		Likelihood ratios (95%CI)		Diagnostic odds ratio (95%CI)	Area under SROC curve (95%CI)
		Sensitivity	Specificity	LHR+	LHR-	DOR
All
VCE	5	0.86 (0.62-0.95)	0.87 (0.72-0.95)	6.7 (2.6-17.8)	0.17 (0.05-0.53)	41 (6-297)	0.93 (0.90-0.95)
DBC	6	0.67 (0.44-0.84)	0.86 (0.72-0.94)	4.9 (2.1-11.3)	0.38 (0.20-0.73)	13 (3-48)	0.84 (0.81-0.87)
Magnification	5	0.90 (0.77-0.96)	0.87 (0.81-0.91)	7.0 (4.6-10.7)	0.11 (0.05-0.28)	62 (18-209)	0.93 (0.91-0.95)
CLE	9	0.87 (0.71-0.95)	0.94 (0.87-0.97)	14.0 (6.1-32.4)	0.14 (0.06-0.33)	101 (23-442)	0.96 (0.94-0.97)
Real-time
Kudo PP	10	0.78 (0.57-0.91)	0.89 (0.80-0.94)	6.9 (3.5-13.5)	0.24 (0.11-0.55)	28 (7-110)	0.91 (0.89-0.94)
CLE	6	0.91 (0.66-0.98)	0.97 (0.94-0.98)	28.4 (13.6-59.1)	0.09 (0.02-0.43)	322 (41-2529)	0.98 (0.97-0.99)
All Kudo PP	12	0.78 (0.61-0.88)	0.86 (0.76-0.92)	5.5 (2.9-10.1)	0.26 (0.14-0.50)	21 (7-66)	0.89 (0.86-0.92)

All using both real-time and image based studies for the different technologies. Real-time, sub-group analysis with studies using only real time Kudo pit pattern (both VCE and DBC) and real-time CLE. All Kudo PP includes all studies using Kudo pit pattern (real-time and image-based). VCE: Virtual chromoendoscopy; DBC: Dye-based chromoendoscopy; CLE: Confocal laser endomicroscopy; Kudo PP: Kudo pit pattern; LHR+: Positive likelihood ratios; LHR-: Negative likelihood ratios; DOR: Diagnostic odd ratios.