Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats

doi:10.3748/wjg.v24.i10.1093

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2018; 24(10): 1093-1106
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1093

Table 2 Results of in vitro release in different incubation media

Prodrug	Incubation media
	Aqueous buffers pH 1.2 and pH 7.4	Stomach and intestinal homogenates	Colon homogenate				Faecal matter
	Aqueous buffers pH 1.2 and pH 7.4	Stomach and intestinal homogenates	K ± SD (min^-1)¹	t_1/2 (min)	% Prodrug hydrolysed	% MPA released	% Prodrug hydrolysed	% MPA released
MGLS	Stable	1.30%	0.0025 ± 0.000978	275	92.6	86.7	63	54
MGAS	Stable	14-19%	0.000108 ± 0.00001	305	79.15	76.4	47	52

¹Average of six readings, follows first-order kinetics. MGLS: Prodrug of mycophenolic acid and D-glucosamine; MGAS: Prodrug of mycophenolic acid and D-galactosamine.

Citation: Chopade SS, Dhaneshwar SS. Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats. World J Gastroenterol 2018; 24(10): 1093-1106
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1093.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1093