Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis

Table 1 Demographic, clinical, and laboratory features of patients included in the study with cryptogenic cirrhosis and hepatitis C virus-related cirrhosis

	Cryptogenic cirrhosis	Hepatitis C virus cirrhosis	P value
No. of patients	102	110
Age at diagnosis (yr), median	66 (38-84)	65 (48-86)	NS
Male sex (M:F ratio)	36 (1:1.8)	58 (3:1)	< 0.01
BMI (mean ± SD)	30 ± 5.7	27.1 ± 3.9	< 0.05
Low alcohol intake	11.8%	12.8%	NS
Past and current smokers	29.4%	27.2%	NS
AST (U/L), mean ± SD	47 ± 43	122 ± 88	< 0.01
ALT (U/L), mean ± SD	35 ± 25	102 ± 63	< 0.01
Υ-GT (U/L), mean ± SD	126 ± 124	82 ± 61	< 0.05
Alph (U/L), mean ± SD	172 ± 181	198 ± 180	NS
Total bilirubin (mg/dL), mean ± SD	2.8 ± 5.2	2.6 ± 4.2	NS
Albumin (g/dL), mean ± SD	3.4 ± 0.8	3.4 ± 0.9	NS
INR, mean ± SD	1.3 ± 0.6	1.4 ± 0.8	NS
Platelets (103/mm3), mean ± SD	120 ± 80	115 ± 60	NS
Creatininemia (mg/dL), mean ± SD	1.1 ± 0.7	1.1 ± 0.6	NS
Ferritin (ng/mL), mean ± SD	163 ± 153	186 ± 162	NS
α-fetoprotein (ng/mL), median	3.4 (0.6-3300)	36 (2-600)	NS
Child-Pugh class A/B/C (%)	47/31/22	48/29/23	NS
HBsAb/HBcAb positive	27.5%	42.7%	< 0.03
Extrahepatic tumors	12.6%	4.4%	NS

NS: Not significant.