Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation

Figure 7 Histology of colon of rats subjected to 2,4,6-trinitrobenzene sulfonic acid. HC: Healthy control showing intact colonic cyto-architecture; DC: Disease control showing mucosal injury characterized by absence of epithelium, architectural distortion and a massive mucosal/submucosal infiltration of inflammatory cells; BBA: β-boswellic acid showing slight mucosal abscess and moderate protection against 2,4,6-trinitrobenzene sulfonic acid (TNBS); SLZ: Sulfasalazine showing corrected cyto-architecture of colon; BH: Prodrug of BBA with L-histidine; BP: Prodrug of BBA with D-phenylalanine; BT: Prodrug of BBA with L-tryptophan; BTY: Prodrug of BBA with L-tyrosine showing corrected morphology of colon; H: L-histidine; P: D-phenylalanine; T: L-tryptophan; TY: L-tyrosine; TY: Showing significant loss of epithelium without mucosal injury providing mild protection against TNBS; BBA + H: Physical mixture of BBA + L-histidine; BBA + P: Physical mixture of BBA + D-phenylalanine; BBA + T: Physical mixture of BBA + L-tryptophan; BBA + TY: Physical mixture of BBA + L-tyrosine showing some loss of epithelial layer while other layers seem reconstructed, indicating moderate protection of cyto-architecture.