Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation

doi:10.3748/wjg.v23.i7.1147

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2017; 23(7): 1147-1162
Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1147

Table 5 Ulcerogenic activity

Code	Ulcer index ± SD¹
HC	1.16 ± 0.40
BBA	3.66 ± 0.51^e
SLZ	7.66 ± 1.21^e
BH	3.16 ± 0.40^e
BP	2.83 ± 0.40^e
BT	3.06 ± 0.89^e
BTY	3.33 ± 0.51^e

¹Average of six readings; One-way ANOVA followed by Dunnett’s multiple comparison test, statistical significance was considered at

^eP < 0.001 vs healthy control. HC: Healthy control; DC: Disease control; BBA: β-boswellic acid; SLZ: Sulfasalazine; BH: Prodrug of BBA with L-histidine; BP: Prodrug of BBA with D-phenylalanine; BT: Prodrug of BBA with L-tryptophan; BTY: Prodrug of BBA with L-tyrosine.

Citation: Sarkate A, Dhaneshwar SS. Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation. World J Gastroenterol 2017; 23(7): 1147-1162
URL: https://www.wjgnet.com/1007-9327/full/v23/i7/1147.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i7.1147