Copyright
©The Author(s) 2017.
World J Gastroenterol. Feb 14, 2017; 23(6): 935-948
Published online Feb 14, 2017. doi: 10.3748/wjg.v23.i6.935
Published online Feb 14, 2017. doi: 10.3748/wjg.v23.i6.935
Table 1 Relative risk of pancreatic cancer in hereditary cancer syndromes
| Inherited syndrome | Relative risk | Cumulative risk of PC | Responsible gene |
| Peutz-Jeghers syndrome[27] | 132 | 11%-36% | STK11 |
| Hereditary pancreatitis[28-31] | 53-87 | 40%-55% | PRSS1 |
| Familial atypical multiple mole melanoma[32,33] | 13-22 | 17% | CDKN2A |
| Hereditary breast-ovarian cancer syndrome[34-37,73] | 4-13 | 2%-7% | BRCA1, BRCA2 |
| Lynch syndrome[38,39] | 5-9 | 4% | MLH1, MSH2, MSH6, PMS2 |
| Familial adenomatous polyposis[40] | 5 | - | APC, MUTYH |
- Citation: Matsubayashi H, Takaori K, Morizane C, Maguchi H, Mizuma M, Takahashi H, Wada K, Hosoi H, Yachida S, Suzuki M, Usui R, Furukawa T, Furuse J, Sato T, Ueno M, Kiyozumi Y, Hijioka S, Mizuno N, Terashima T, Mizumoto M, Kodama Y, Torishima M, Kawaguchi T, Ashida R, Kitano M, Hanada K, Furukawa M, Kawabe K, Majima Y, Shimosegawa T. Familial pancreatic cancer: Concept, management and issues. World J Gastroenterol 2017; 23(6): 935-948
- URL: https://www.wjgnet.com/1007-9327/full/v23/i6/935.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i6.935