Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study

Table 6 Multivariate analysis

Equation variables	Regression coefficient B	Wald	Significance	Exp (B)	95%CI for Exp (B)
					Lower limit	Upper limit
PPI therapy	0.241	2.015	0.156	1.273	0.912	1.776
Gastrectomy	0.600	0.676	0.411	1.821	0.436	7.604
Any resecting gastric surgery	0.875	4.369	0.037	2.399	1.056	5.450
Stenoses	1.033	7.011	0.008	2.809	1.308	6.033
Gastroparesis	1.016	3.244	0.072	2.762	0.914	8.345
Any colon resection	0.479	3.012	0.083	1.614	0.940	2.772
Any medical immunosuppression	0.428	4.380	0.036	1.534	1.028	2.291
Levothyroxine therapy	1.070	20.980	0.000	2.916	1.845	4.609
Diabetes mellitus	-0.453	3.223	0.073	0.636	0.388	1.042
Sigmoid diverticulosis	0.832	4.835	0.028	2.298	1.095	4.823

Binary logistic regression analysis for risk factors for SIBO. All parameters found to be significant in previous analyses were used for analysis with binary logistic regression. A history of gastric surgery, stenoses, medical immunosuppression, levothyroxine therapy and sigmoid diverticulosis showed statistical significance as contributors to SIBO. SIBO: Small intestinal bacterial overgrowth; Exp: Exponent.