Nomogram based on tumor-associated neutrophil-to-lymphocyte ratio to predict survival of patients with gastric neuroendocrine neoplasms

Table 3 Variables associated with recurrence-free survival according to the Cox proportional hazards regression model

Variable	Univariate analysis			Multivariate analysis
	Hazard ratio	95%CI	P value	Hazard ratio	95%CI	P value
Age (yr)			0.790
≤ 70	Reference
> 70	1.083	0.602-1.950
Gender			0.126
Male	Reference
Female	0.608	0.322-1.149
Tumor site			0.770
Upper	Reference
Middle	0.825	0.389-1.751
Lower	0.885	0.465-1.682
Mixed	1.348	0.588-3.091
Tumor size (cm)			0.004			0.671
≤ 3.5	Reference			Reference
> 3.5	2.740	1.385-5.421		NA	NA
Lymphovascular invasion			0.144
No	Reference
Yes	1.471	0.876-2.468
ASA status			0.190
1 + 2	Reference
3 + 4	1.551	0.804-2.993
Postoperative complication			0.029
No	Reference			Reference		0.305
Yes	1.869	1.065-3.278		NA	NA
Surgical approach			0.249
Endo/laparoscopic	Reference
Open	0.733	0.432-1.243
Depth of invasion			0.005			0.557
T1	Reference			Reference
T2	5.328	0.483-58.789		NA	NA
T3	11.722	1.587-86.603		NA	NA
T4	19.301	2.629141.682		NA	NA
Lymph node ratio			< 0.001			< 0.001
0	Reference			Reference
> 0, ≤ 0.2	5.490	1.623-18.568		3.338	0.962-11.581
> 0.2, ≤ 0.4	8.091	2.393-27.351		4.6	1.317-16.066
> 0.4	17.946	5.239-61.480		10.266	2.906-36.266
Ki-67 index (%)			0.004			< 0.001
≤ 2	Reference			Reference
≥ 3, ≤ 20	3.013	0.639-14.203		1.501	0.305-7.393
> 20	7.047	1.709-29.053		4.999	1.140-21.927
TA-NLR			< 0.001			< 0.001
≤ 0.21	Reference			Reference
> 0.21	3.366	1.890-5.992		2.974	1.630-5.426

TA-NLR: Tumor-associated neutrophil-to-lymphocyte ratio.