Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway

Figure 2 Down-regulation of miR-30a-3p/5p correlates with esophageal squamous cell carcinoma progression and clinical prognosis. Analyses of miR-30a-3p and miR-30a-5p expression were performed in 99 cases of esophageal squamous cell carcinoma tissues, which was normalized by U6 expression. Red lines within figures indicate the mean values of miR-30a-3p and miR-30a-5p expression fold changes. A: Expression fold changes of miR-30a-3p (left) and miR-30a-5p (right) in different statuses of differentiation of ESCC, with no significant difference found between different groups; B: Expression fold changes of miR-30a-3p (left) and miR-30a-5p (right) in different T classifications of ESCC, ^aP < 0.05; C: Expression fold changes of miR-30a-3p (left) and miR-30a-5p (right) in different N classifications of ESCC, ^aP < 0.05; D: Overall survival time was analyzed by the Kaplan-Meier method in ESCC patients with relatively high (n = 49) or low (n = 50) expression of miR-30a-3p (left, P = 0.004) and miR-30a-5p (right, P = 0.006), respectively.