Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients

Table 4 Pathway analyses from genetic associations with adverse events from immunochip analyses

Type of adverse event	Pathway	Number of genes	P value	P value (Bonferroni)
Any	JAK-STAT signaling pathway	13	3.98 × 10-6	7.96 × 10-4
Any	Measles	12	8.87 × 10-6	0.0018
Any	IBD	8	3.05 × 10-5	0.0061
Any	Cytokine-cytokine receptor interaction	16	5.03 × 10-5	0.0100
Any	Toxoplasmosis	10	5.49 × 10-5	0.0110
Infusion	JAK-STAT signaling pathway	12	3.68 × 10-5	0.0074
Infusion	Measles	12	8.24 × 10-6	0.0016
Infusion	IBD	7	2.11 × 10-4	0.0420
Infusion	Cytokine-cytokine receptor interaction	14	4.98 × 10-4	0.0990
Infusion	Toxoplasmosis	11	9.02 × 10-6	0.0018
Allergic	JAK-STAT signaling pathway	12	2.96 ×10-5	0.0060
Allergic	Measles	12	6.6 × 10-6	0.0010
Allergic	IBD	7	1.84 × 10-4	0.0370
Allergic	Cytokine-cytokine receptor interaction	14	4.02 ×10-4	0.0800
Allergic	Toxoplasmosis	9	2.25 ×10-4	0.0450

IBD: Inflammatory bowel disease.