Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy

Table 3 Adverse events in first- and second-line eradication therapies n (%)

	First-line eradication therapy				Second-line eradication therapy
	VPZ	EPZ	RPZ	LPZ	VPZ	EPZ	RPZ	LPZ
Adverse events	61 (11.2)	39 (7.7)	9 (10.1)	12 (5.7)	6 (7.9)	14 (13.5)	3 (12.5)	7 (12.3)
Diarrhoea/soft stool	29 (47.5)	25 (64.1)	5 (55.6)	8 (66.7)	4 (66.7)	6 (43.0)	3 (100)	5 (71.4)
Eruption	7 (11.5)	3 (7.7)	2 (22.2)	2 (16.7)	0	3 (21.4)	0	0
Constipation	6 (10.0)	3 (7.7)	0	0
Dysgeusia	3 (5.0)	3 (7.7)	1 (11.1)	0	0	1 (7.1)	0	1 (14.3)
Nausea and vomiting	2 (3.3)	2 (5.1)	0	1 (8.3)	0	1 (7.1)	0	0
Abdominal pain	5 (8.2)	2 (5.1)	0	0	1 (16.7)	2 (14.3)	0	0
Appetite loss	3 (5.0)	0	0	0
General fatigue	2 (3.3)	1 (2.6)	0	0	1 (16.7)	0	0	0
Heartburn	1 (1.6)	0	0	1 (8.3)
Headache	1 (1.6)	0	0	0	0	0	0	1 (14.3)
Fever	1 (1.6)	0	0	0
Flatulence	0	0	1 (11.1)	0
Haematuria	1 (1.6)	0	0	0
Vertigo					0	1 (7.1)	0	0

VPZ: Vonoprazan group; EPZ: Esomeprazole group; RPZ: Rabeprazole group; LPZ: Lansoprazole group.